I've been hearing rumors that during the E3 convention last week, during a press-only preview, Fallout 4 was announced. The game, which is 55% done, would center around Boston and the surrounding communities.
If this is true it would be a mixed blessing. On one hand, it would obviously be completely awesome but on the other hand, at least for me, I could envision the part of my brain deriving enjoyment from video games being utterly burnt out forever. This game would prevent me from ever needing to buy another video game again.
It's a risk I'm willing to take.
Considering just how great both Fallout three and New Vegas were at translating locales and atmosphere to a post-apocalyptic universe, I could imagine some amazing places in Fallout Boston: MIT, the T, Boston Harbor, Fenway, the Big Dig, the list goes on.